5hmo

Structural highlights

Function

[MYO10_BOVIN] In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation (By similarity). Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate, which are then moved relative to actin filaments. Stimulates the formation and elongation of filopodia. Regulates cell shape, cell spreading and cell adhesion. Plays a role in formation of the podosome belt in osteoclasts.^{[1] [2] [3] [4] [5] [6] [7] [8] [9]}

References

1. ↑ Homma K, Saito J, Ikebe R, Ikebe M. Motor function and regulation of myosin X. J Biol Chem. 2001 Sep 7;276(36):34348-54. Epub 2001 Jul 16. PMID:11457842 doi:http://dx.doi.org/10.1074/jbc.M104785200
2. ↑ Zhang H, Berg JS, Li Z, Wang Y, Lang P, Sousa AD, Bhaskar A, Cheney RE, Stromblad S. Myosin-X provides a motor-based link between integrins and the cytoskeleton. Nat Cell Biol. 2004 Jun;6(6):523-31. Epub 2004 May 23. PMID:15156152 doi:http://dx.doi.org/10.1038/ncb1136
3. ↑ Kovacs M, Wang F, Sellers JR. Mechanism of action of myosin X, a membrane-associated molecular motor. J Biol Chem. 2005 Apr 15;280(15):15071-83. Epub 2005 Feb 10. PMID:15705568 doi:http://dx.doi.org/10.1074/jbc.M500616200
4. ↑ Bohil AB, Robertson BW, Cheney RE. Myosin-X is a molecular motor that functions in filopodia formation. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12411-6. Epub 2006 Aug 7. PMID:16894163 doi:10.1073/pnas.0602443103
5. ↑ McMichael BK, Cheney RE, Lee BS. Myosin X regulates sealing zone patterning in osteoclasts through linkage of podosomes and microtubules. J Biol Chem. 2010 Mar 26;285(13):9506-15. doi: 10.1074/jbc.M109.017269. Epub 2010, Jan 17. PMID:20081229 doi:http://dx.doi.org/10.1074/jbc.M109.017269
6. ↑ Sun Y, Sato O, Ruhnow F, Arsenault ME, Ikebe M, Goldman YE. Single-molecule stepping and structural dynamics of myosin X. Nat Struct Mol Biol. 2010 Apr;17(4):485-91. doi: 10.1038/nsmb.1785. Epub 2010 Apr, 4. PMID:20364131 doi:http://dx.doi.org/10.1038/nsmb.1785
7. ↑ Watanabe TM, Tokuo H, Gonda K, Higuchi H, Ikebe M. Myosin-X induces filopodia by multiple elongation mechanism. J Biol Chem. 2010 Jun 18;285(25):19605-14. doi: 10.1074/jbc.M109.093864. Epub, 2010 Apr 13. PMID:20392702 doi:http://dx.doi.org/10.1074/jbc.M109.093864
8. ↑ Plantard L, Arjonen A, Lock JG, Nurani G, Ivaska J, Stromblad S. PtdIns(3,4,5)P(3) is a regulator of myosin-X localization and filopodia formation. J Cell Sci. 2010 Oct 15;123(Pt 20):3525-34. doi: 10.1242/jcs.069609. PMID:20930142 doi:http://dx.doi.org/10.1242/jcs.069609
9. ↑ Umeki N, Jung HS, Sakai T, Sato O, Ikebe R, Ikebe M. Phospholipid-dependent regulation of the motor activity of myosin X. Nat Struct Mol Biol. 2011 Jun 12;18(7):783-8. doi: 10.1038/nsmb.2065. PMID:21666676 doi:http://dx.doi.org/10.1038/nsmb.2065