Topoisomerase binding protein (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks[1]. TopBP1 contains BRCT domains which are ca. 100 amino acid long tandem repeat which bind phosphor-peptides.
3D structures of topoisomerase binding protein
Updated on 18-September-2016
3jve, 3pd7 – hTopBP1 BRCT 6 domain – human
2xnh, 2xnk – hTopBP1 BRCT 0-2 domains
3olc – hTopBP1 N terminal
3uen – hTopBP1 BRCT 4-5 domains
3ueo – hTopBP1 BRCT 4-5 domains + phosphor-peptide
3al2 – hTopBP1 BRCT 7-8 domains
3al3 – hTopBP1 BRCT 7-8 domains + Fanconi anemia group J protein peptide
References
- ↑ Yamane K, Kawabata M, Tsuruo T. A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator. Eur J Biochem. 1997 Dec 15;250(3):794-9. PMID:9461304
