5syn

Structural highlights

Function

[LYPA2_HUMAN] May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.^[1]

References

1. ↑ Tomatis VM, Trenchi A, Gomez GA, Daniotti JL. Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. PLoS One. 2010 Nov 30;5(11):e15045. doi: 10.1371/journal.pone.0015045. PMID:21152083 doi:http://dx.doi.org/10.1371/journal.pone.0015045