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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Function
Zepatier is a combination drug combating genotypes 1 and 4 of chronic hepatitis C viral (HCV) infections in adults. It is composed of Elbasvir and Grazoprevir. Elbasvir NS5A is small-molecule NS5A replication complex inhibitor a non-enzymatic protein whose exact mechanism of action is unknown.It is essential for viral replication and assembly of hepatitis C.It possess in vitro activity against major HCV genotypes and variants resistant to earlier inhibitors. Elbasvir prevents viral production at the early stage of assembly in turn preventing spread of the virus. Grazoprevir is a macrocyclic compound that is able to reversibly bind to the protease. NS3/4A is a serine protease also essential for viral replication. It is responsible for cleavage and processing of the HCV polyprotein. It is hypothesized that the protease is utilized to circumvent immune response at the primary stages of infection.
Disease
Relevance
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
