1qf5
From Proteopedia
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| , resolution 2.0Å | |||||||
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| Ligands: | , , , | ||||||
| Activity: | Adenylosuccinate synthase, with EC number 6.3.4.4 | ||||||
| Related: | 1QF4
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE
Overview
Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.
About this Structure
1QF5 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:10556888
Page seeded by OCA on Sun Mar 30 23:12:38 2008
