Structural highlights
3v8f is a 3 chain structure with sequence from Pyrho. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
|
| Ligands: | , , |
| Related: | 2nwl, 2nww, 2nwx, 1xfh, 3kbc, 3v8g |
| Gene: | PH1295 (PYRHO) |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Publication Abstract from PubMed
We report a structure of a trimeric glutamate transporter homolog from Pyrococcus horikoshii with two protomers in an inward facing state and the third in an intermediate conformation between the outward and inward facing states. The intermediate shows a cavity in the thinnest region of the transporter, which is potentially accessible to extracellular and cytoplasmic solutions. Our findings suggest a structural principle by which transport intermediates may mediate uncoupled permeation of polar solutes.
Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog.,Verdon G, Boudker O Nat Struct Mol Biol. 2012 Feb 12;19(3):355-7. doi: 10.1038/nsmb.2233. PMID:22343718[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Verdon G, Boudker O. Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog. Nat Struct Mol Biol. 2012 Feb 12;19(3):355-7. doi: 10.1038/nsmb.2233. PMID:22343718 doi:http://dx.doi.org/10.1038/nsmb.2233
