2n9x

Structural highlights

Function

[MLP3B_HUMAN] Involved in formation of autophagosomal vacuoles (autophagosomes). [FUND1_HUMAN] Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.^[1]

References

1. ↑ Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, Ma Q, Zhu C, Wang R, Qi W, Huang L, Xue P, Li B, Wang X, Jin H, Wang J, Yang F, Liu P, Zhu Y, Sui S, Chen Q. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol. 2012 Jan 22;14(2):177-85. doi: 10.1038/ncb2422. PMID:22267086 doi:http://dx.doi.org/10.1038/ncb2422