Function
Latrophilin (LAT) or adhesion G protein-coupled receptor is the major brain receptor for α-latroxin - a black widow spidertoxin which stimulates strong neuronal exocytosis in vertebrates[1]. LAT is cleaved proteolitically into 2 fragments which reassociate upon binding an agonist and upon reassociation cause release of calcium from intracellular stores and massive release of neurotransmitter.
Disease
LAT-3 variant confers susceptibility to ADHD and predicts effectiveness of stimulant medication[2].
Structural highlights