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1r2q

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Revision as of 20:22, 30 March 2008 by OCA (Talk | contribs)
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Image:1r2q.gif


PDB ID 1r2q

Drag the structure with the mouse to rotate
, resolution 1.05Å
Ligands: , ,
Gene: RAB5A OR RAB5 (Homo sapiens)
Related: 1N6H, 1N6I, 1N6K, 1N6L, 1N6N


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution


Overview

Rab5 is a GTPase that regulates early endosome fusion. Its GTPase domain crystal structure is reported here at 1.05 A resolution in complex with a GTP-analog molecule. It provides the highest resolution three-dimensional model so far obtained for proteins from the Ras-like GTPase family. This study allows extension of structural examination of the GTPase machinery as well as of high-resolution protein structures in general. For example, a buried water-molecule network was observed underneath the switch regions, which is consistent with the functional roles of these regions in the molecular-switching process. Furthermore, residues of multiple conformation and clustered distribution of anisotropic thermal motions of the protein molecule may have general implications for the function of Ras-like GTPases.

About this Structure

1R2Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution., Terzyan S, Zhu G, Li G, Zhang XC, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):54-60. Epub 2003, Dec 18. PMID:14684892

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