1r54
From Proteopedia
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| , resolution 1.85Å | |||||||
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| Ligands: | , , , | ||||||
| Gene: | ADAM33 (Homo sapiens) | ||||||
| Related: | 1R55
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the catalytic domain of human ADAM33
Overview
Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling. We have determined the crystal structure of the Adam33 catalytic domain in complex with the inhibitor marimastat and the inhibitor-free form. The structures reveal the polypeptide fold and active site environment resembling that of other metalloproteases. The substrate-binding site contains unique features that allow the structure-based design of specific inhibitors of this enzyme.
About this Structure
1R54 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the catalytic domain of human ADAM33., Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V, J Mol Biol. 2004 Jan 2;335(1):129-37. PMID:14659745
Page seeded by OCA on Sun Mar 30 23:23:25 2008
Categories: Homo sapiens | Single protein | Hammond, G. | Mirza, U A. | Orth, P. | Prosise, W W. | Reicher, P. | Strickland, C. | Taremi, S S. | Wang, W. | Xiao, L. | Yarosh-Tomaine, T. | Zou, J. | Adam | Asthma | Metalloprotease
