1r8o
From Proteopedia
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| , resolution 1.83Å | |||||||
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| Related: | 1R8N
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds
Overview
The crystallographic structure of a novel trypsin inhibitor (CTI) from Copaifera langsdorffii is reported. The structure was solved by MIRAS procedure and refined to a crystallographic residual of 17.3% (R(free) = 20.3%) at 1.8 A resolution. Two isomorphous derivatives were obtained by quick cryo-soaking approach. CTI is the first structure of a member of Kunitz (STI) family formed by two noncovalently bound polypeptide chains and only one disulfide bridge. A standard Kunitz-type inhibitor has a single polypeptide chain and two disulfide bridges. Structural features granting CTI high inhibitory activity are discussed.
About this Structure
1R8O is a Protein complex structure of sequences from Copaifera langsdorffii. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of an unusual Kunitz (STI) type trypsin inhibitor from Copaifera langsdorffii., Krauchenco S, Nagem RA, da Silva JA, Marangoni S, Polikarpov I, Biochimie. 2004 Mar;86(3):167-72. PMID:15134830
Page seeded by OCA on Sun Mar 30 23:24:50 2008
