Structural highlights
Publication Abstract from PubMed
The transcription regulator PbrR691, one of the MerR family proteins, shows extremely high sensitivity and selectivity toward Pb(II) in Ralstonia metallidurans CH34. Here, we present the crystal structure of PbrR691 in complex with Pb(II) at 2.0 A resolution. The Pb(II) coordinates with three conserved cysteines and adopts a unique trigonal-pyramidal (hemidirected) geometry. To our knowledge, the PbrR691-Pb(II) structure provides the first three-dimensional visualization of a functional hemidirected lead(II) thiolate coordinate geometry in a protein.
Structural Basis for the Selective Pb(II) Recognition of Metalloregulatory Protein PbrR691.,Huang S, Liu X, Wang D, Chen W, Hu Q, Wei T, Zhou W, Gan J, Chen H Inorg Chem. 2016 Dec 19;55(24):12516-12519. Epub 2016 Nov 30. PMID:27989185[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Huang S, Liu X, Wang D, Chen W, Hu Q, Wei T, Zhou W, Gan J, Chen H. Structural Basis for the Selective Pb(II) Recognition of Metalloregulatory Protein PbrR691. Inorg Chem. 2016 Dec 19;55(24):12516-12519. Epub 2016 Nov 30. PMID:27989185 doi:http://dx.doi.org/10.1021/acs.inorgchem.6b02397
