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1rh7
From Proteopedia
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| , resolution 3.106Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | RETNLB or FIZZ2 (Mus musculus) | ||||||
| Domains: | Resistin | ||||||
| Related: | 1RFX, 1RGX
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Resistin-like beta
Overview
Resistin, founding member of the resistin-like molecule (RELM) hormone family, is secreted selectively from adipocytes and induces liver-specific antagonism of insulin action, thus providing a potential molecular link between obesity and diabetes. Crystal structures of resistin and RELMbeta reveal an unusual multimeric structure. Each protomer comprises a carboxy-terminal disulfide-rich beta-sandwich "head" domain and an amino-terminal alpha-helical "tail" segment. The alpha-helical segments associate to form three-stranded coiled coils, and surface-exposed interchain disulfide linkages mediate the formation of tail-to-tail hexamers. Analysis of serum samples shows that resistin circulates in two distinct assembly states, likely corresponding to hexamers and trimers. Infusion of a resistin mutant, lacking the intertrimer disulfide bonds, in pancreatic-insulin clamp studies reveals substantially more potent effects on hepatic insulin sensitivity than those observed with wild-type resistin. This result suggests that processing of the intertrimer disulfide bonds may reflect an obligatory step toward activation.
About this Structure
1RH7 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Disulfide-dependent multimeric assembly of resistin family hormones., Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L, Science. 2004 May 21;304(5674):1154-8. PMID:15155948
Page seeded by OCA on Sun Mar 30 23:28:07 2008
Categories: Mus musculus | Single protein | Burley, S K. | NYSGXRC, New York Structural GenomiX Research Consortium. | Patel, S D. | Rajala, M W. | Scherer, P E. | Shapiro, L. | Glucose uptake | Hormone | New york structural genomix research consortium | Nysgxrc | Protein structure initiative | Psi | Resistin/fizz family | Structural genomic
