Structural highlights 
5hf0 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.  
 | 
| Ligands: | , , ,  | 
| Related: | 4xec, 5hf2 | 
| Activity: | Dihydrofolate reductase, with EC number 1.5.1.3  | 
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT | 
  Function 
[DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.