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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Function
Guanine nucleotide exchange factor (GEF) of the Rho/Rac GTPases [3], including Ras and Cdc42.
Disease
Relevance
Structural highlights
The Vav1 are (from N ter to C ter): a calponin-homology (CH) domain, an acidic (Ac) domain, a DBL-homology (DH) domain also known as a rhoGEF domain, a pleckstrin-homology (PH) domain, a phorbol esters/diacylglycerol binding (C1) domain and Src-homology (SH) 3 and 2 domains. [4] [5]
(residues 1 - 119): When the CH domain is deleted, Vav has a phosphorylation-independant GEF activity. Studies on Vav3 implies that CH plays a role in inhibition via its interactions with the (between the residue 49 in CH and 181 in Ac), DH and regions (C1 interacts with L101 and L104 of CH). The contacts with DH and C1 seem passively driven by the interactions between Ac and CH, though. [6]
(residues 134 - 187): contains the Tyrosine (Y174) which activates Vav activity when phosphorylated.
(residues 194 - 373): present in every Rho/rac GEF, it is the active site of the GTP exchange with the C1 domain in Vav. It always has a PH domain at its C terminal.
