Epoxidase

From Proteopedia

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spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Hydroxypropylphosphonic acid epoxidase (HppE) is involved in the biosynthesis of the antibiotic fosfomycin[1]. HppE is a Zn+2/Fe+2-dependent enzyme. Halohydrin epoxidase (HHE) is involved in the degradation of halohydrins by the displacement of a halogen in halohydrins to produce the epoxide[2]. Disease Relevance Structural highlights

3D structures of epoxidase

Updated on 06-February-2017

References

1. ↑ McLuskey K, Cameron S, Hammerschmidt F, Hunter WN. Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14221-6. Epub 2005 Sep 26. PMID:16186494
2. ↑ Watanabe F, Yu F, Ohtaki A, Yamanaka Y, Noguchi K, Yohda M, Odaka M. Crystal structures of halohydrin hydrogen-halide-lyases from Corynebacterium sp. N-1074. Proteins. 2015 Dec;83(12):2230-9. doi: 10.1002/prot.24938. Epub 2015 Oct 16. PMID:26422370 doi:http://dx.doi.org/10.1002/prot.24938