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Contents 1 Zinc-finger 1 2 Origin 3 Structure 4 Function 5 Interactions 6 References

Zinc-finger 1

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Origin

Zinc fingers were first identified in a study of transcription in the transcription factor TFIIIA of the African clawed frog, Xenopus laevis, conducted in Aaron Klug's lab.

Structure

The “finger” refers to the secondary structures ( and β-sheet) that are held together by the .

Function

This small protein motif is a transcriptional regulator. It recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. regulate eukaryotic gene expression

Interactions

The zinc-fingers usually interact with the outside of B-DNA. When interacting with DNA, the zinc fingers bind in the major groove of B-DNA and wrap part way around the double helix.

References

Zinc Fingers. (n.d.). Retrieved February 08, 2017, from http://www.ebi.ac.uk/interpro/potm/2007_3/Page2.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC554390/

http://epigenie.com/key-epigenetic-players/chromatin-modifying-and-dna-binding-proteins/zinc-finger-proteins/

http://www.rcsb.org/pdb/explore.do?structureId=1ZAA