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Human core-PIC in the initial transcribing state (no IIS)
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Function
In eukaryotic transcription initiation, a large multi-subunit pre-initiation complex (PIC) that assembles at the core promoter is required for the opening of the duplex DNA and identification of the start site for transcription by RNA polymerase II. Human core-PIC helps in the transcription of DNA into using four ribonucleotide triphosphates as substrates. The molecule is a component of RNA Polymerase II, and thus is integral in the synthesis of mRNA precursors and functional non-coding RNA. Within the complex is the , which holds the TATA box binding protein- this polypeptide will bind to the TATA consensus sequence and help to initiate transcription of an mRNA transcript. The P chain is assisted by IF-2, located on the .
What it Interacts With
Human core-PIC interacts with DNA, ribonucleotide triphosphates, mRNA, and DNA Polymerase II.
Where is interacts
The molecule interacts with DNA in the nucleus, where the mRNA transcript is synthesized.
Where it originates
Human core-PIC originates in homo sapiens, or the modern day human.
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