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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Biological Function
Structural Overview
Binding of DNA
The have been found to be the SER 54 and 57 along with HIS 58.
Zinc Binding
Zinc is an allosteric inhibitor to CzrA. Two zinc +2 ions may bind to the dimer, at the location of the helix from each monomer. As zinc binds, the alpha 5 helices to inhibit the DNA binding residues. As CzrA is a transcriptional repressor, binding of zinc to the dimer will activate the czr operon. Furthermore, CzrA must be in its dimer form for zinc to bind. The is formed by two residues from each monomer, so zinc cannot bind to the monomer. The is formed by Asp84 and His86 from one monomer, and His97 and His100 from the other monomer.
The zinc ion forms a tetrahedral complex with the four residues (Figure 1). This allows other metal ions to act as allosteric inhibitors to CzrA.
References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
