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spinqualitylabelsall models Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Introduction

Noxafil, also known as Posaconazole, is an antifungal drug used to treat fungal infections caused by Candida and Aspergillus species, as well as treat other fungal infections such as chromoblastomycosis, mycetoma, and coccidioidomycosis. Noxafil is also often used when other antifungal medicines are tolerated or if the patient is immunocompromised. Noxafil is under the triazole class of antifungal drugs and works by inhibiting the production of ergosterol, an important factor in fungi cell membranes, leading to prevention of cell growth and ultimately death.

Structure

• Chemical Formula: C₃₇H₄₂F₂N₈O₄
• Molecular Weight: 700.792 g/mol
• IUPAC name: 4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

The structure of Posaconazole allows it to potently act as a triazole broad-spectrum antifungal drug that was derived from the antifungal agent, Itraconazole. The differences in structure are that the Chlorine substituents in the aromatic ring on the left-hand side of the images are replaces with Fluorines and that the triazolone sidechain is hydroxylated in the Posaconazole structure^[1]