Sandbox Reserved 1231

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This Sandbox is Reserved from Jan 17 through June 31, 2017 for use in the course Biochemistry II taught by Jason Telford at the Maryville University, St. Louis, USA. This reservation includes Sandbox Reserved 1225 through Sandbox Reserved 1244.

To get started: Click the edit this page tab at the top. Save the page after each step, then edit it again. Click the 3D button (when editing, above the wikitext box) to insert Jmol. show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page. Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc. More help: Help:Editing

Contents 1 Titin Structure 2 Function 3 Disease 4 Relevance 5 Structural highlights 6 References

Titin Structure

Titin is a giant sarcomeric protein that is found in both cardiac and skeletal muscle. Since this protein extends from the Z-line to the M-line, this protein plays a crucial role in the maintenance of the sarcomere structural integrity and it also plays a role as a shock absorber in sarcomeres. Titin essentially regulates the sarcomeric length and performs adequate adjustments of passive tension when the length varies. When the Titin is stretched the thermal disturbances are expecting it to follow the Maxwell path (global minimizer of its energy which doesn't involve energy dissipation or hysteresis. This path involves a barrier crossing at the transitions and overcoming this barrier will cause disturbances.

Function

The primary function of Titin is to stabilize the thick filaments by centering between the thin filaments. It also prevents the sarcomere from over-stretching by recoiling the sarcomere like a spring.

Disease

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

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References

Castro-Ferreira, Ricardo, and Ricardo Fontes-Carvalho. "SciFinder." The role of titin in the modulation of cardiac function and its pathophysiological implications. Sociedade Brasileira De Cardiologia, n.d. Web. 13 Feb. 2017.

Benichou, Tamar, and Sefi Givli. The hidden ingenuity in titin structure. American Institute of Physics, n.d. Web. 13 Feb. 2017.