5tbx

Structural highlights

Function

[CIRBP_HUMAN] Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.^{[1] [2]}

References

1. ↑ Yang C, Carrier F. The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response. J Biol Chem. 2001 Dec 14;276(50):47277-84. Epub 2001 Sep 26. PMID:11574538 doi:http://dx.doi.org/10.1074/jbc.M105396200
2. ↑ Yang R, Weber DJ, Carrier F. Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18. Nucleic Acids Res. 2006 Mar 2;34(4):1224-36. Print 2006. PMID:16513844 doi:http://dx.doi.org/10.1093/nar/gkj519