Glucokinase is also known as human hexokinase IV [1]. It is an enzyme that involves in the regulation of glucose homeostasis. Liver and pancreatic cells use glucokinase converts glucose molecule to glucose 6 phosphate.
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You may include any references to papers as in: the use of JSmol in Proteopedia [2] or to the article describing Jmol [3] to the rescue.
Structure and Function
Glucokinase is a protein contains 465 amino acid residues which make up two domains, including a and a .
When glucose molecule binds to the of glucoskinase, it forms hydrogen bonds with . At the , either glucokinase activators (GKA) or glucokinase inhibitor (GKI) will bind to regulate the activity of glucokinase by changing the confirmation. JSmol structure shows an example of GK-GKA complex, where the GKA bind to the allosteric site.
