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Function
The macromolecule LprG biochemical function is phosphatidylinositol binding which interacts selectively and noncovalently with glycerophospholipids and phosphorylated derivatives.
Disease
Tuberculosis is an infectious disease that is the second leading cause of death worldwide. Mycobacterium tuberculosis is an intracellular bacterial pathogen in infected macrophages. It contributes to antibiotic resistance and plays a critical role in regulating host response and aid survival of pathogen. LprG determines the distribution components of mycobacterium tuberculosis cell envelope.
Relevance
Structural highlights
LprG (4ZRA) consists of two chains A and C containing alpha-beta folds. Chain A contains 10 anti-parallel ß-strands by 6 α-helices which defines the central cavity entrance. The TAG glyceryl group is located at the entrance and has a conserved orientation. At the cavity entrance the hydophilic glyceryl interacts with . There are three acyl chains bound within the cavity sn1, sn2, and sn3 and form interactions with hydrophobic residue side chains within the cavity. The third acyl chain is exposed to the solvent and the other two (sn1 and sn2) are buried and not shown. The sn3 chain is near two hydrophobic grooves, these grooves could facilitate the binding of TAG with other longer acyl chains.
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