Function
This protein is the most widely used biomarker of kidney function. If kidney function and glomerular filtration rate decline, the blood levels of cystatin C rise. Also, the serum levels of cystatin C are a more precise test of kidney function than serum creatinine levels.
Disease
Cystatin C is an endogenous cysteine proteinase inhibitor. It belongs to the type 2 cystatin superfamily. The diagnostic value of cystatin as a marker of kidney of dysfunction has been researched in a lot of clinical studies on adults, children and the elderly.
In most of these clinical studies, cystatin C is turned out to be a better diagnostic accuracy than serum creatinine in discriminating normal from impaired kidney function. So cystatin C is a key factor to see if we diagnosis kidney diseases.
Besides, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. Furthermore, it is also turned out to play a key role in brain disorders involving in amyloid, for example,Alzheimer's disease.
Relevance
Structural highlights
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