Sandbox Reserved 1239

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This Sandbox is Reserved from Jan 17 through June 31, 2017 for use in the course Biochemistry II taught by Jason Telford at the Maryville University, St. Louis, USA. This reservation includes Sandbox Reserved 1225 through Sandbox Reserved 1244.

To get started: Click the edit this page tab at the top. Save the page after each step, then edit it again. Click the 3D button (when editing, above the wikitext box) to insert Jmol. show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page. Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc. More help: Help:Editing

Contents 1 Function 2 Structure 3 Disease 4 Relevance 5 Structural highlights 6 References

Function

Occludin is one of the proteins absolutely necessary in maintaining tight junctions of cells. Tight junctions preserve the integrity of polarized cells, allowing homeostasis to continue. Polarized cells can be broadly defined as cells that have two dynamically different faces for functionally different purposes. Each face is different in protein and membrane composition. For example, intestinal cells have an apical surface and basolateral surface. The apical surface faces the lumen and intakes material, while the basolateral surface interacts with blood vessels. Proteins and lipids can diffuse laterally and freely through a membrane [1]. However, in cells that are meant to be polarized, it would be catastrophic to have proteins exchanged between apical and basolateral surfaces due to their pivotal roles in homeostasis. Tight junctions restrict lateral diffusion, keeping cell surfaces polarized [2].

Structure

Disease

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

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References