5kbz

Structural highlights

Function

[PKSL1_ASPPA] Combines a hexanoyl starter unit and 7 malonyl-CoA extender units to synthesize the precursor norsolorinic acid anthrone (noranthrone) in the aflatoxin biosynthesis pathway. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase.^{[1] [2]}

References

1. ↑ Yu J, Chang PK, Ehrlich KC, Cary JW, Bhatnagar D, Cleveland TE, Payne GA, Linz JE, Woloshuk CP, Bennett JW. Clustered pathway genes in aflatoxin biosynthesis. Appl Environ Microbiol. 2004 Mar;70(3):1253-62. PMID:15006741
2. ↑ Crawford JM, Thomas PM, Scheerer JR, Vagstad AL, Kelleher NL, Townsend CA. Deconstruction of iterative multidomain polyketide synthase function. Science. 2008 Apr 11;320(5873):243-6. doi: 10.1126/science.1154711. PMID:18403714 doi:http://dx.doi.org/10.1126/science.1154711