1ACJ* shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
Tacrine was the first cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
Tacrine’s ringed structure is stacked between the aromatic rings of Trp84 and Phe330.
- Harel et al Silman & Sussman (1993) "Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase" PNAS, 90, 9031-5.