Structural highlights
1e9w is a 1 chain structure with sequence from Streptomyces azureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| NonStd Res: | , , , , , , , |
| Related: | 1d8t, 1oln, 2c77, 2jq7, 2zjp, 3cf5 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[THCL_STRAJ] Has bacteriocidal activity. Inhibits bacterial protein biosynthesis by acting on the elongation factor Tu (EF-Tu) (By similarity).
Publication Abstract from PubMed
The structure of a tetragonal crystal form of thiostrepton has been solved using the anomalous dispersive effects of five S atoms from high-redundancy data collected to 1.33 A resolution at the Cu Kalpha wavelength. Data measured to 1.02 A resolution with a synchrotron source were used for refinement. Details of the molecular structure, intramolecular and intermolecular interactions are given.
Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur.,Bond CS, Shaw MP, Alphey MS, Hunter WN Acta Crystallogr D Biol Crystallogr. 2001 May;57(Pt 5):755-8. Epub 2001, Apr 24. PMID:11320328[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Bond CS, Shaw MP, Alphey MS, Hunter WN. Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur. Acta Crystallogr D Biol Crystallogr. 2001 May;57(Pt 5):755-8. Epub 2001, Apr 24. PMID:11320328
