Pre-mRNA-splicing factor

Function

Pre-mRNA-splicing factors (Prp) are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing^[1].

• Prp3b is part of the U2 small nuclear ribonucleoproteins complex (U2 snRNP)
  
• Prp8 functions as a scaffold which mediates the ordered assembly of spliceosomal proteins and snRNAs. For details see Prp8
  
• Prp18 and Bud31 are essential for the catalytic step in pre-mRNA splicing process.
  
• snRNA-associated-splicing factor 24 binds preferentially to the U4/U6 hybrid snRNAs. For details see Prp24
  
• For Prp19 see Prp19
  
• Prp31 functions in forming the U4/U5-U6 tri-snRNP.
  
• For Prp40 see Prp40.
  
• Prpcwc2 is a yeast splicing factor which plays a role in the generation of a functional splicing center Prp RBM22 is the human homolog of Prpcwc2.
  
• Prpcwc26 or Bud13 belongs to the pre-mRNA retention and splicing complex RES.
  

Disease

Mutations in Prp8 and Prp31 cause retinitis pigmentosa^[2].

Structural highlights

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