User:Benjamin Elliott/Crystal Structure of the Bromodomain-PHD Finger Module of Human Transcriptional Co-Activator CBP in complex with Acetylated Histone 4 Peptide (H4K20ac)

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Function

Bromodomains, in general, function as acetyl-lysine binding domains to regulate gene transcription in chromatin. This particular bromodomain of CBP binds with relatively high specificity to Lys20-acetylated histone H4 (H4K20), though this preference is not well understood.

Disease

Relevance

Bromodomains have become a popular target for their role in human disease since they recognize an epigenetic tag.

Structural highlights

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