Structural highlights
3acg is a 1 chain structure with sequence from Clojo. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , |
| Related: | 3acf, 3ach, 3aci |
| Gene: | celA (CLOJO) |
| Activity: | Cellulase, with EC number 3.2.1.4 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The crystal structures of a carbohydrate-binding module (CBM) family 28 domain of endoglucanase Cel5A from Clostridium josui have been determined in ligand-free and complex forms with cellobiose, cellotetraose, and cellopentaose as the first complex structures of this family. In the cleft of a beta-sandwich fold, the ligands are recognized by stacking interactions and hydrogen bonds. Conformations of the bound cellooligosaccharides are similar to those in crystals and solution but clearly different from the cellulose structure. Interestingly, the glucan chain bound on CBM28 is in the opposite direction of that bound to CBM17, although these families share significant structural similarity.
Recognition of cellooligosaccharides by a family 28 carbohydrate-binding module.,Tsukimoto K, Takada R, Araki Y, Suzuki K, Karita S, Wakagi T, Shoun H, Watanabe T, Fushinobu S FEBS Lett. 2010 Mar 19;584(6):1205-11. Epub 2010 Feb 14. PMID:20159017[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Tsukimoto K, Takada R, Araki Y, Suzuki K, Karita S, Wakagi T, Shoun H, Watanabe T, Fushinobu S. Recognition of cellooligosaccharides by a family 28 carbohydrate-binding module. FEBS Lett. 2010 Mar 19;584(6):1205-11. Epub 2010 Feb 14. PMID:20159017 doi:10.1016/j.febslet.2010.02.027
