Structural highlights
1yj6 is a 3 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , |
| Related: | 1gtu, 1xw6, 1xwk |
| Gene: | GSTM1, GST1 (HUMAN) |
| Activity: | Glutathione transferase, with EC number 2.5.1.18 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[GSTM1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Patskovsky Y, Patskovska L, Almo SC, Listowsky I. Transition state model and mechanism of nucleophilic aromatic substitution reactions catalyzed by human glutathione S-transferase M1a-1a. Biochemistry. 2006 Mar 28;45(12):3852-62. PMID:16548513 doi:http://dx.doi.org/10.1021/bi051823+
