3cz3

Structural highlights

Function

[2B_TAV] Acts as suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Forms a homodimer to measure siRNA duplex in a length-preferencemode. Binds to both siRNA duplexes (19bp) and long siRNA duplexes (30bp).^{[1] [2] [3]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Li HW, Lucy AP, Guo HS, Li WX, Ji LH, Wong SM, Ding SW. Strong host resistance targeted against a viral suppressor of the plant gene silencing defence mechanism. EMBO J. 1999 May 17;18(10):2683-91. PMID:10329615 doi:http://dx.doi.org/10.1093/emboj/18.10.2683
2. ↑ Ding SW, Anderson BJ, Haase HR, Symons RH. New overlapping gene encoded by the cucumber mosaic virus genome. Virology. 1994 Feb;198(2):593-601. PMID:8291242 doi:http://dx.doi.org/10.1006/viro.1994.1071
3. ↑ Shi BJ, Ding SW, Symons RH. In vivo expression of an overlapping gene encoded by the cucumoviruses. J Gen Virol. 1997 Jan;78 ( Pt 1):237-41. PMID:9010309