Structural highlights
3h3j is a 2 chain structure with sequence from Staac. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , |
| Related: | 3d0o, 3d4p |
| Gene: | ldh1, SACOL0222 (STAAC) |
| Activity: | L-lactate dehydrogenase, with EC number 1.1.1.27 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[LDH1_STAAC] Appears to be the primary factor that allows S.aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Richardson AR, Libby SJ, Fang FC. A nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity. Science. 2008 Mar 21;319(5870):1672-6. PMID:18356528 doi:http://dx.doi.org/319/5870/1672
