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1ztq
From Proteopedia
| |||||||
| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Gene: | MMP13 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the catalytic domain of MMP-13 complexed with WAY-033
Overview
A potent, selective series of MMP-13 inhibitors has been derived from a weak (3.2 microM) inhibitor that did not bear a zinc chelator. Structure-based drug design strategies were employed to append a Zn-chelating group to one end of the molecule and functionality to enhance selectivity to the other. A compound from this series demonstrated rat oral bioavailability and efficacy in a bovine articular cartilage explant model.
About this Structure
1ZTQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Identification of potent and selective MMP-13 inhibitors., Wu J, Rush TS 3rd, Hotchandani R, Du X, Geck M, Collins E, Xu ZB, Skotnicki J, Levin JI, Lovering FE, Bioorg Med Chem Lett. 2005 Sep 15;15(18):4105-9. PMID:16005220
Page seeded by OCA on Mon Mar 31 01:41:31 2008
Categories: Homo sapiens | Single protein | Collins, E. | Du, X. | Geck, M. | Hotchandani, R. | III, T S.Rush. | Levin, J I. | Lovering, F. | Skotnicki, J. | Wu, J. | Xu, Z B. | Collagenase | Hydrolase | Hydrophobic s1s' | Hydroxamate | Metalloprotease | Mmp-13 | Mmp | P1' group | Zinc chelator
