5hdt

Structural highlights

Function

[PDS5B_HUMAN] Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.^{[1] [2] [3]} [WAPL_HUMAN] Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.^{[4] [5] [6] [7] [8] [9]}

References

1. ↑ Geck P, Maffini MV, Szelei J, Sonnenschein C, Soto AM. Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10185-90. PMID:10963680
2. ↑ Losada A, Yokochi T, Hirano T. Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts. J Cell Sci. 2005 May 15;118(Pt 10):2133-41. Epub 2005 Apr 26. PMID:15855230 doi:http://dx.doi.org/10.1242/jcs.02355
3. ↑ Shintomi K, Hirano T. Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1. Genes Dev. 2009 Sep 15;23(18):2224-36. doi: 10.1101/gad.1844309. Epub 2009 Aug, 20. PMID:19696148 doi:10.1101/gad.1844309
4. ↑ Oikawa K, Ohbayashi T, Kiyono T, Nishi H, Isaka K, Umezawa A, Kuroda M, Mukai K. Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression. Cancer Res. 2004 May 15;64(10):3545-9. PMID:15150110 doi:10.1158/0008-5472.CAN-03-3822
5. ↑ Kueng S, Hegemann B, Peters BH, Lipp JJ, Schleiffer A, Mechtler K, Peters JM. Wapl controls the dynamic association of cohesin with chromatin. Cell. 2006 Dec 1;127(5):955-67. Epub 2006 Nov 16. PMID:17113138 doi:10.1016/j.cell.2006.09.040
6. ↑ Gandhi R, Gillespie PJ, Hirano T. Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Curr Biol. 2006 Dec 19;16(24):2406-17. Epub 2006 Nov 16. PMID:17112726 doi:10.1016/j.cub.2006.10.061
7. ↑ Shintomi K, Hirano T. Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1. Genes Dev. 2009 Sep 15;23(18):2224-36. doi: 10.1101/gad.1844309. Epub 2009 Aug, 20. PMID:19696148 doi:10.1101/gad.1844309
8. ↑ Terret ME, Sherwood R, Rahman S, Qin J, Jallepalli PV. Cohesin acetylation speeds the replication fork. Nature. 2009 Nov 12;462(7270):231-4. PMID:19907496 doi:nature08550
9. ↑ Nishiyama T, Ladurner R, Schmitz J, Kreidl E, Schleiffer A, Bhaskara V, Bando M, Shirahige K, Hyman AA, Mechtler K, Peters JM. Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell. 2010 Nov 24;143(5):737-49. doi: 10.1016/j.cell.2010.10.031. PMID:21111234 doi:10.1016/j.cell.2010.10.031