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2afv

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Revision as of 22:52, 30 March 2008 by OCA (Talk | contribs)
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Image:2afv.gif


PDB ID 2afv

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, resolution 3.00Å
Ligands: , ,
Activity: Precorrin-8X methylmutase, with EC number 5.4.1.2
Related: 2AFR


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis


Overview

The leptospira cbiC encodes the enzyme catalyzing the methyl rearrangement reaction of the cobalamin biosynthesis pathway. The protein has been cloned and overexpressed as a His-tagged recombinant protein in Escherichia coli. The crystal structures have been solved in two crystal forms (P4(2)2(1)2 and P3(1)21) diffracting to 3.0 and 2.3A resolution, respectively. The structures are similar to the precorrin-8x methyl mutase (CobH), an enzyme of the aerobic pathway to vitamin B12.

About this Structure

2AFV is a Single protein structure of sequence from Leptospira interrogans. Full crystallographic information is available from OCA.

Reference

The crystal structure of putative precorrin isomerase CbiC in cobalamin biosynthesis., Xue Y, Wei Z, Li X, Gong W, J Struct Biol. 2006 Mar;153(3):307-11. Epub 2005 Dec 27. PMID:16427313

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