Structural highlights
Function
[ANXA5_CHICK] Collagen-binding protein.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The crystal structure of chicken annexin V has been solved by molecular replacement and refined at 2.25 A. The final R factor is 19.7% with good geometry. The chicken annexin V structure is very similar to the human annexin V structure, with four similar domains each containing five helices. The structure includes three calcium ions in domains I, II, and IV, each bound by the characteristic K-G-X-G-T-(38 residues)-D/E motif. In view of the structural similarity between human and chicken annexin V, we suggest that they have a common vital function which developed early in evolutionary history.
Structure of chicken annexin V at 2.25-A resolution.,Bewley MC, Boustead CM, Walker JH, Waller DA, Huber R Biochemistry. 1993 Apr 20;32(15):3923-9. PMID:8471604[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Bewley MC, Boustead CM, Walker JH, Waller DA, Huber R. Structure of chicken annexin V at 2.25-A resolution. Biochemistry. 1993 Apr 20;32(15):3923-9. PMID:8471604
