Ribosome biogenesis protein

From Proteopedia

spinqualitylabelsall models Ribosome biogenesis protein (PDB code 3hay) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Ribosome biogenesis proteins are factors which contribute to the maturation of the ribosome. Interactive 3D figure on right side shows: Ribosome biogenesis protein Nop10 (pink) complexed with pseudouridine synthase (grey), GAR1 (green), ribosomal protein L7AE (yellow), H/ACA RNA (magenta) and RNA containing pseudouridine (cyan) (PDB code 3hay) Erb1 Nop7 and Ytm1 are essential for the correct ribosomal RNA processing[1]. Nop10 is part of the nucleoprotein particle which catalyzes RNA pseudouridylation and direct processing of ribosomal RNA[2]. Utp30 is a ribosomal L1 domain-containing protein which is part of the 90S preribosome[3]. Tsr1 is essential for cytoplasmic steps in the 40S ribosomal subunit maturation[4]. Nep1 is essential in 18S ribosomal RNA procssing[5]. Bms1 is part of a complex required for the 40S ribosomal subunit maturation[6]. Structural highlights The Nop10 containing nucleoprotein particle contains the modified pseudouridine which interacts with residues of the pseudouridine synthase[7].

3D Structures of ribosome biogenesis protein

Updated on 14-December-2017

References

1. ↑ Marcin W, Neira JL, Bravo J. The Carboxy-Terminal Domain of Erb1 Is a Seven-Bladed ss-Propeller that Binds RNA. PLoS One. 2015 Apr 16;10(4):e0123463. doi: 10.1371/journal.pone.0123463., eCollection 2015. PMID:25880847 doi:http://dx.doi.org/10.1371/journal.pone.0123463
2. ↑ Hamma T, Reichow SL, Varani G, Ferre-D'Amare AR. The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs. Nat Struct Mol Biol. 2005 Dec;12(12):1101-7. Epub 2005 Nov 15. PMID:16286935 doi:10.1038/nsmb1036
3. ↑ Hu J, Zhu X, Ye K. Structure and RNA recognition of ribosome assembly factor Utp30. RNA. 2017 Sep 26. pii: rna.062695.117. doi: 10.1261/rna.062695.117. PMID:28951391 doi:http://dx.doi.org/10.1261/rna.062695.117
4. ↑ McCaughan UM, Jayachandran U, Shchepachev V, Chen ZA, Rappsilber J, Tollervey D, Cook AG. Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases. Nat Commun. 2016 Jun 2;7:11789. doi: 10.1038/ncomms11789. PMID:27250689 doi:http://dx.doi.org/10.1038/ncomms11789
5. ↑ Taylor AB, Meyer B, Leal BZ, Kotter P, Schirf V, Demeler B, Hart PJ, Entian KD, Wohnert J. The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site. Nucleic Acids Res. 2008 Mar;36(5):1542-54. Epub 2008 Jan 21. PMID:18208838 doi:10.1093/nar/gkm1172
6. ↑ Delprato A, Al Kadri Y, Perebaskine N, Monfoulet C, Henry Y, Henras AK, Fribourg S. Crucial role of the Rcl1p-Bms1p interaction for yeast pre-ribosomal RNA processing. Nucleic Acids Res. 2014;42(15):10161-72. doi: 10.1093/nar/gku682. Epub 2014 Jul, 26. PMID:25064857 doi:http://dx.doi.org/10.1093/nar/gku682
7. ↑ Liang B, Zhou J, Kahen E, Terns RM, Terns MP, Li H. Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA. Nat Struct Mol Biol. 2009 Jul;16(7):740-6. Epub 2009 May 28. PMID:19478803 doi:10.1038/nsmb.1624