Function
Sodium-hydrogen exchange regulatory factors (NHERF) are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton[1]. NHERF-1 is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane[2].
Relevance
NHERF-1 inhibitors represent a potentially effective therapeutic approach to the treatment of hear failure[3]. NHERF-1 has a vital role in kidney cell survival[4]. NHERF are known to be involved in pathophysiologies of many brain diseases like epilepsy, Alzhheimer's disease, neuropathic pain and stroke.
Structural highlights
NHERF interacts with ion transporters and receptors via its PDZ domains and with the merlin, ezrin, radixin and moesin proteins via its c-terminal. The CXCR2 peptide binds the second PDZ domain hydrophobic cleft[5].
