Structural highlights
Disease
[PHKG2_HUMAN] Glycogen storage disease due to liver phosphorylase kinase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
Function
[PHKG2_HUMAN] Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).[1]
References
- ↑ Brushia RJ, Walsh DA. Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure. Front Biosci. 1999 Sep 15;4:D618-41. PMID:10487978
