Structural highlights
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The crystal structure of the human immunodeficiency virus type 1 (HIV-1) neutralizing, murine Fab 83.1 in complex with an HIV-1 gp120 V3 peptide has been determined to 2.57 A resolution. The conformation of the V3 loop peptide in complex with Fab 83.1 is very similar to V3 conformations seen previously with two other neutralizing Fabs, 50.1 and 59.1. The repeated identification of this same V3 conformation in complex with three very different, neutralizing antibodies indicates that it is a highly preferred structure for V3 loops on some strains of the HIV-1 virus.
Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop.,Stanfield RL, Ghiara JB, Ollmann Saphire E, Profy AT, Wilson IA Virology. 2003 Oct 10;315(1):159-73. PMID:14592768[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Stanfield RL, Ghiara JB, Ollmann Saphire E, Profy AT, Wilson IA. Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop. Virology. 2003 Oct 10;315(1):159-73. PMID:14592768
