Sandbox Reserved 1412

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spinqualitylabelsall models Bacteriorhodopsin Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.

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Contents 1 Rhodopsin 2 Structure 3 Function 4 References

Rhodopsin

Bacteriorhodopsin is found in Archaea, where it reacts in the presence of light. When hit by light and bound to a proton, the protein undergoes a conformational change and pumps protons out of the cell, creating an electrochemical gradient.

Structure

The protein's main structure is ^[1].

The is at the center of the protein and is bound to the alpha helices. In bacterial rhodopsin, the retinal functions as a proton pump by a conformation from all trans to cis-13. The goes from cis to trans when the retinal is hit by light, and this change pumps protons out of the cell.

Function

This proton pump is used to create a gradient that can be used for things like ATP synthesis.

References

1. ↑ Ernst OP, Lodowski DT, Elstner M, Hegemann P, Brown LS, Kandori H. Microbial and animal rhodopsins: structures, functions, and molecular mechanisms. Chem Rev. 2014 Jan 8;114(1):126-63. doi: 10.1021/cr4003769. Epub 2013 Dec 23. PMID:24364740 doi:http://dx.doi.org/10.1021/cr4003769