6bzf

Structural highlights

Function

[ZIP2_YEAST] Required for initiation of meiotic chromosome synapsis. Involved in synaptonemal complex formation, a structure that tethers a pair of homologous chromosomes along their lengths and plays a central role in recombination and homolog segregation during meiosis. Required for the normal localization of MSH4 to chromosomes.^{[1] [2] [3] [4] [5] [6] [7]} [SPO16_YEAST] Necessary for efficient spore formation.

References

1. ↑ San-Segundo PA, Roeder GS. Pch2 links chromatin silencing to meiotic checkpoint control. Cell. 1999 Apr 30;97(3):313-24. PMID:10319812
2. ↑ Bailis JM, Smith AV, Roeder GS. Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins. Mol Cell Biol. 2000 Jul;20(13):4838-48. PMID:10848609
3. ↑ Agarwal S, Roeder GS. Zip3 provides a link between recombination enzymes and synaptonemal complex proteins. Cell. 2000 Jul 21;102(2):245-55. PMID:10943844
4. ↑ Novak JE, Ross-Macdonald PB, Roeder GS. The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distribution. Genetics. 2001 Jul;158(3):1013-25. PMID:11454751
5. ↑ Peoples-Holst TL, Burgess SM. Multiple branches of the meiotic recombination pathway contribute independently to homolog pairing and stable juxtaposition during meiosis in budding yeast. Genes Dev. 2005 Apr 1;19(7):863-74. doi: 10.1101/gad.1293605. PMID:15805472 doi:http://dx.doi.org/10.1101/gad.1293605
6. ↑ Tsubouchi T, Zhao H, Roeder GS. The meiosis-specific zip4 protein regulates crossover distribution by promoting synaptonemal complex formation together with zip2. Dev Cell. 2006 Jun;10(6):809-19. doi: 10.1016/j.devcel.2006.04.003. PMID:16740482 doi:http://dx.doi.org/10.1016/j.devcel.2006.04.003
7. ↑ Chua PR, Roeder GS. Zip2, a meiosis-specific protein required for the initiation of chromosome synapsis. Cell. 1998 May 1;93(3):349-59. PMID:9590170