Thyroid hormone receptor

Revision as of 11:03, 19 February 2018 by Michal Harel (Talk | contribs)

Structure of human thyroid hormone receptor ligand-binding domain complex with thyroid hormone and cacodylate (PDB entry 1xzx)

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3D Structures of thyroid hormone receptor

Updated on 19-February-2018

3uvv – hTR a1 LBD + retinoic acid receptor + retinoic acid + triiodo-thyronine

1q4x – hTR b1 LBD + agonist
1r6g, 3imy, 3jzc, 1n46 – hTR b1 LBD + thyromimetic
1nax – hTR b1 LBD + ligand
2pin, 2j4a – hTR b1 LBD + inhibitor

3m9e – hTR b1 DBD + DNA
2nll – hTR b1 DBD + retinoic acid receptor + DNA

↑ Forrest D, Erway LC, Ng L, Altschuler R, Curran T. Thyroid hormone receptor beta is essential for development of auditory function. Nat Genet. 1996 Jul;13(3):354-7. doi: 10.1038/ng0796-354. PMID:8673137 doi:http://dx.doi.org/10.1038/ng0796-354
↑ Cheng SY. Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance. Trends Endocrinol Metab. 2005 May-Jun;16(4):176-82. doi:, 10.1016/j.tem.2005.03.008. PMID:15860414 doi:http://dx.doi.org/10.1016/j.tem.2005.03.008
↑ Kim WG, Cheng SY. Thyroid hormone receptors and cancer. Biochim Biophys Acta. 2013 Jul;1830(7):3928-36. doi:, 10.1016/j.bbagen.2012.04.002. Epub 2012 Apr 6. PMID:22507269 doi:http://dx.doi.org/10.1016/j.bbagen.2012.04.002
↑ Kunitake JM, Hartman N, Henson LC, Lieberman J, Williams DE, Wong M, Hershman JM. 3,5,3'-triiodothyroacetic acid therapy for thyroid hormone resistance. J Clin Endocrinol Metab. 1989 Aug;69(2):461-6. doi: 10.1210/jcem-69-2-461. PMID:2753985 doi:http://dx.doi.org/10.1210/jcem-69-2-461