From Proteopedia

proteopedia linkproteopedia link

This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.

To get started: Click the edit this page tab at the top. Save the page after each step, then edit it again. Click the 3D button (when editing, above the wikitext box) to insert Jmol. show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page. Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc. More help: Help:Editing

Contents 1 2r7e Overview 2 Ligands 3 Function 4 Disease 5 Relevance 6 References

2r7e Overview

spinqualitylabelsall models 2r7e 3-D Structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image 2r7e is a cool protein. Structural highlights 2r7e is a 2 chain structure found in humans. It has 5 associated ligands ( , , BMA, MAN, NAG) and is coded for by 2 different genes, F8 and F8C. 2r7e has both and

secondary structure. Alterations in this structure can lead to improper location of ligands, leading to failed protein function.

Ligands

2r7e has 5 ligands, which are binding sites for other proteins in Coagulation Factor VIII

Function

2r7e is a protein that makes up part of Coagulation Factor VIII, which is a protein complex involved in blood clotting in humans. Coagulation Factor VIII works with calcium and phosholipids to Factor X to its activated form Xa.

Disease

Mutations in 2r7e can alter the structure of Coagulation Factor VIII, leading to hemophilia a.

Relevance

Yay!

References

h http://www.uniprot.org/uniprot/P00451