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Sandbox Reserved 1336

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Revision as of 21:17, 20 February 2018 by Student (Talk | contribs)
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Contents

Structure

Insert caption here

Drag the structure with the mouse to rotate


Function

Platlet formation/clotting

Phospholipid movement

Apoptosis

Disease

Scott syndrome is a rare human disease caused by a mutation that affects TMEM16 proteins and results in the inability to form platelets correctly.

Relevance

Structural highlights

This protein prefers to form homodimers, which means that the complex is made of two identical chains of itself.

There are multiple sites where calcium ions can bind.

Once Ca ions bind to these sites, the chloride channel can open.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737519/ https://www.rcsb.org/pdb/protein/C7Z7K1?addPDB=4WIS

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