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Function
Epithelial-cadherin (1-213), or E-cadherin, is a calcium-dependent cell adhesion protein. E-cadherin help regulate bacterial interaction with mammalian tissues and play a key role in blastula formation.
Disease
E-cadherin is a tumor suppressor gene. Degradation or loss of function of the gene is thought to be linked to metastasis and proliferation of tumors. In particular, mutations in the E-cadherin gene are linked to a series of cancers, including gastric, breast, colorectal, ovarian, and thyroid cancers.
Relevance
Structural highlights
E-cadherin is 213 amino acids long. The molecule is comprised of five cadherin extensions, a transmembrane region, and a cytoplasmic tail. In epithelial cells, E-cadherin contains cell-to-cell junctions often located close to actin-filaments within the cytoskeleton of a cell. E-cadherin is a homodimer, meaning that it is made up of two identical subunits.
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
