Sandbox Reserved 1407

From Proteopedia

Revision as of 21:37, 25 February 2018 by Student (Talk | contribs)

(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)

This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.

To get started:

Click the edit this page tab at the top. Save the page after each step, then edit it again.
Click the 3D button (when editing, above the wikitext box) to insert Jmol.
show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

1 Heavy Meromyosin
2 Organism of Origin
3 Protein Structure
4 Function
5 Significance
6 References

Heavy Meromyosin

This is .

Organism of Origin

This protein originated in tarantulas, Red Junglefowls and humans.

Protein Structure

Heavy meromyosin (HMM) is a subunit of myosin. There are two fragments that make up HMM: S-1 and S-2. S-1 projects out on an angle whereas S-2 is comprised of globular heads that can bind to actin. Together, these are called a myosin cross bridge. There are four distinct macromolecules that comprise HMM, including (196 amino acids: magenta), (150 amino acids: blue), (971 amino acids: gold), and (973 amino acids: purple).

Function

Heavy meromyosin is a part of the actin-myosin system. Heavy meromyosin (and light meromyosin) are subunits of myosin. HMM is the globular head portion of myosin which determines the rate of muscle contraction in an organism. Actin binding capacity and ATPase activity are dependent on HMM.

Significance

Heavy meromyosin is important for muscle contractions in a multitude of organisms. It plays an important role in microtubule-based movement as a part of the myosin complex. The ability for myosin to bind to actin and use ATP to create mechanical energy is dependent on heavy meromyosin. Without this protein, muscle contraction and mobility would be limited.